Three icons board the luxury cruise ship procedural drama Doctor Odyssey on an all-new episode this Thursday night, March 27th at 9pm ET/PT on ABC and streaming on Hulu.

In the episode entitled Sophisticated Ladies, Knots Landing favorite and General Hospital alum, Donna Mills (ex-Abby and ex-Madeline, respectively), along with Charlie’s Angels icon, Jaclyn Smith (ex-Kelly) and Grammy-Award winning music superstar, Shania Twain are all-aboard for the romance and medical drama that ensues.

According to the official longlines for the episode from ABC, “Tristan strives to prove himself to Avery; Captain Massey is shaken by shocking news; Sophisticated Ladies Week brings a disruptive passenger onboard; the crew navigates the delicate care of a terminal patient.”

Doctor Odyssey comes from creator, Ryan Murphy and stars Joshua Jackson (ex-Dawson Creek) as Dr Max Bankman, the new on-board doctor for a luxury cruise ship where the staff works hard and plays harder. It’s all-hands-on-deck as Max and his small but mighty medical team navigate unique medical crises and each other, miles from shore. The cast also includes: Don Johnson, Phillipa Soo and Sean Teale.

In the just released promo for Thursday night’s episode; it features Donna Mills in scenes with Joshua Jackson’s Max, where her character says, “Are you attracted to me?” Meanwhile, Shania Twain shares scenes with Don Johnson’s Captain Massey, and in her entrance says to him, “Happy to see me?” Clearly they have a past together!

Donna Mills also took to her Instagram on Tuesday to share the promo in which she is featured, and wrote, “The trailer just dropped for my episode of Dr. Odyssey. Airing this Thursday night on ABC. #drodyssey#sophisticatedladies ”